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10 Best Acne Serums 2025 in the United States

From leading brands and best sellers available on the web.

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Obagi Medi

Obagi Medical

Obagi Medical ELASTIderm Facial Serum, 1.0 oz Pack of 2

#1

Winner

CeraVe Ret

CeraVe

CeraVe Retinol Serum for Post-Acne Marks and Skin Texture | Pore Refining, Resurfacing, Brightening Facial Serum with Retinol and Niacinamide | Fragrance Free, Paraben Free & Non-Comedogenic| 1 Oz

Sponsored

Obagi Medi

Obagi Medical

Obagi Medical ELASTIderm Facial Serum, 1.0 oz Pack of 2

#2
La Roche-P

La Roche-Posay

La Roche-Posay Pure 10% Vitamin C Serum For Face With Hyaluronic Acid & Salicylic Acid, Hydrating & Brightening Serum, Boost Radiance & Reduce Wrinkles, Paraben Free, Stocking Stuffers

#3
Paula's Ch

Paula's Choice

Paula's Choice BOOST 10% Azelaic Acid Booster Cream Gel, Licorice Extract & Salicylic Acid, Oil-Free Skin Brightening Serum, 1 Ounce

#4
CeraVe Acn

CeraVe

CeraVe Acne Control Gel, 2% Salicylic Acid Acne Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Acne Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

#5
La Roche-P

La Roche-Posay

La Roche-Posay Effaclar Salicylic Acid Acne Treatment to Minimize Pores, Clear Acne Blemishes and Post Acne Marks

#6
Paula's Ch

Paula's Choice

Paula's Choice CLEAR Daily Skin Clearing Treatment with Benzoyl Peroxide, Treats and Prevents Mild to Severe Acne & Breakouts, Fragrance-Free, 2.25 Fl. Oz.

#7
Minimalist

Minimalist

Minimalist 2% Salicylic Acid Serum For Acne, Blackhead & Open Pores | Reduces Excess Oil & Bumpy Texture | BHA Liquid Exfoliant for Acne Prone & Oily Skin | For Women & Men | 1 Fl Oz/30ml

#8
Paula's Ch

Paula's Choice

Paula's Choice BOOST 10% Niacinamide Booster, Vitamin B3, Vitamin C & Licorice Extract Serum, Pore Minimizer, 0.67 Ounce

#9
Neutrogena

Neutrogena

Neutrogena Stubborn Marks PM Treatment with Retinol SA, Face-Exfoliating Treatment to Help Reverse the Look of Post-Acne Marks & Uneven Skin Tone, Oil-Free, Non-Comedogenic, PM Treatment, unscented, 1.0 Fl Oz

#10
The Ordina

The Ordinary

The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz

More products we considered

Collagen Serum For Face by Natural Outcome Skin Care - Ultra Impact Marine Collagen Peptides Serum for Face - Facial Moisturizer Anti Aging Serum Gel for Firming, Lifting and Reducing Wrinkles, 1 oz

Collagen Serum For Face by Natural Outcome Skin Care - Ultra Impact Marine Collagen Peptides Serum for Face - Facial Moisturizer Anti Aging Serum Gel for Firming, Lifting and Reducing Wrinkles, 1 oz

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SkinDaily Niacinamide Serum for Face -1oz- Vitamin B3 Pore Minimizer Dermatologist Recommend Concentration - Targets Aging Skin, Wrinkles, Dark Spots - Superior Moisturizer and Skin Brightening

SkinDaily Niacinamide Serum for Face -1oz- Vitamin B3 Pore Minimizer Dermatologist Recommend Concentration - Targets Aging Skin, Wrinkles, Dark Spots - Superior Moisturizer and Skin Brightening

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Pacifica Face Oil Serum - Flower Fix Bi-Phase Hydrating Skin Barrier - w/Hyaluronic Acid & Natural Botanical Ingredients - for Dry Sensitive Skin Vegan & Cruelty-Free Dermatologist Approved

Pacifica Face Oil Serum - Flower Fix Bi-Phase Hydrating Skin Barrier - w/Hyaluronic Acid & Natural Botanical Ingredients - for Dry Sensitive Skin Vegan & Cruelty-Free Dermatologist Approved

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Vitamin C Face Serum - Anti Aging & Brightening Facial Serum - With Hyaluronic Acid Gotu Kola & Jojoba Oil - Natural & Organic - Foxbrim Naturals 1oz

Vitamin C Face Serum - Anti Aging & Brightening Facial Serum - With Hyaluronic Acid Gotu Kola & Jojoba Oil - Natural & Organic - Foxbrim Naturals 1oz

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Pacifica Liquid Face Bronzing Drops - Sunny Glow Liquid Bronzer For Face & Skin - Illuminating Highlighting Makeup -w/Vitamin C, for Cheeks & Forehead Vegan Cruelty Free Dermatologist Tested

Pacifica Liquid Face Bronzing Drops - Sunny Glow Liquid Bronzer For Face & Skin - Illuminating Highlighting Makeup -w/Vitamin C, for Cheeks & Forehead Vegan Cruelty Free Dermatologist Tested

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