10 Best Arthritis Cream For Knees 2025 in the United States

Biofreeze Professional Strength Pain Relief Roll-On is designed for individuals seeking relief from arthritis and other pain conditions in areas such as knees, lower back, and more. One of its standout features is the use of menthol as the active ingredient, which provides a cooling sensation that helps alleviate pain quickly.

The roll-on application method is convenient and hands-free, thanks to the massaging roller ball, making it easy to target specific areas without getting cream on your hands. It also absorbs rapidly into the skin, allowing for nearly instantaneous relief without a greasy residue, making it suitable for use throughout the day, even when on the go, as it is TSA-approved for travel.

For those sensitive to scents, it's worth noting that the menthol aroma is quite strong, which some users may find overwhelming. The product is non-systemic and free from NSAIDs and addictive substances, making it a safer alternative for regular use without the risk of systemic side effects. The duration of relief can vary, with some users experiencing only temporary alleviation of symptoms. Biofreeze Professional is particularly beneficial for those looking for a quick, non-messy, and portable pain relief solution, especially if they can tolerate a strong menthol scent.

Penetrex Joint & Muscle Therapy Trio is designed to provide relief for various parts of the body, including knees, back, neck, hands, and feet. It uses a blend of natural ingredients like arnica, vitamin B6, MSM, and boswellia, which are known for their anti-inflammatory and pain-relieving properties. This cream is non-greasy, non-sticky, and non-staining, which makes it convenient to use without worrying about residue. Additionally, it is paraben-free, cruelty-free, and vegan, making it suitable for individuals with sensitive skin or those who prefer ethical products.

The scent is mild, avoiding the strong odors that are often associated with other pain relief creams. Users are instructed to apply the cream 3-4 times daily for the first week to ten days, then continue as needed. This might be a bit frequent for those looking for a more low-maintenance option. The product's absorption rate is effective as it is designed to penetrate deeply to target discomfort at the source.

Penetrex can be used alone or in combination with other therapies like heating pads or ice packs, which can be beneficial for comprehensive pain management. The product is highly trusted with over 2 million users, indicating its effectiveness and reliability. However, it might be pricier compared to other options given its premium formulation and the suggested frequent application.

Voltaren Arthritis Pain Gel is designed to provide powerful relief for arthritis pain, particularly in the knees. The gel contains a nonsteroidal anti-inflammatory drug (NSAID) which helps in reducing inflammation and pain directly at the source, providing a more effective alternative to oral pain medications. It’s clinically proven to improve mobility and reduce stiffness when used consistently four times a day for at least a week.

The gel is non-greasy, has a clean scent, and is free from parabens and dyes, making it suitable for those with sensitive skin. The easy open cap is a thoughtful feature, especially useful for individuals with limited hand mobility due to arthritis. Each pack contains two 100g tubes, offering substantial quantity for frequent use.

Users need to be aware that the gel should not be applied to more than two joints simultaneously, and it may take up to seven days to see significant pain relief. Those looking for a quick fix might find this a drawback. Additionally, consistent application is necessary to maintain pain relief. Despite these points, Voltaren is highly recommended by doctors and is eligible for HSA and FSA, which adds to its accessibility and convenience.