10 Best Bed Bug Killers 2025 in the United States

The MGK Crossfire® Bed Bug Concentrate is a professional-grade bed bug killer designed to combat pyrethroid-resistant bed bug strains. It features a patented formula with two active ingredients, Clothianidin and Metofluthrin, along with Piperonyl Butoxide as a synergist, making it highly effective in killing bed bugs at all life stages, including eggs.

One of its standout strengths is that it begins working within minutes of exposure, providing quick knockdown and kill. Additionally, it is non-staining, making it suitable for direct application on mattresses and other indoor areas without causing damage to fabrics or surfaces. The concentrate's ease of use is notable, as a 13-ounce bottle can be mixed to create one gallon of finished product, simplifying the preparation and application process for users.

MGK, the manufacturer, has a long-standing reputation in the pest control industry, adding a layer of trust and reliability to the product. As with any chemical treatment, safety precautions must be observed to prevent harm to humans and pets. MGK Crossfire® Bed Bug Concentrate is a potent and efficient solution for severe bed bug infestations, particularly those involving pyrethroid-resistant strains, and is recommended for residential, institutional, and commercial use.

Ortho Home Defense Max Bed Bug, Flea, and Tick Killer with Comfort Wand is a liquid spray that targets bed bugs, bed bug eggs, fleas, and ticks. The product is designed to kill even pyrethroid-resistant bed bugs, making it effective against tough infestations. It's suitable for indoor use, particularly as a spot treatment around areas like bed frames, baseboards, and mattress seams.

The Comfort Wand included with the spray allows for precise application to hard-to-reach places, enhancing ease of use and targeting efficiency. The 1-gallon container ensures ample supply for larger spaces or repeated treatments, and the spray form is convenient for quick application.

Users should consider safety precautions when using this chemical-based product, especially around children and pets. Additionally, because it's part of the Ortho Bed Bug Solution System, optimal results are achieved when used alongside Step 1: Detect and Trap and Step 3: Cracks and Crevices products. While highly effective, the residual effect might require follow-up treatments to ensure complete eradication. The product’s weight and dimensions make it somewhat bulky, which might be inconvenient for some users.