10 Best Bed Bug Spray For Mattress 2025 in the United States

The Hot Shot Ready-to-Use Bed Bug Killer Spray is designed to effectively tackle bed bugs and their eggs as well as fleas and dust mites. Its active ingredients enable it to kill bed bugs at all life stages, including larvae and eggs, making it a comprehensive solution. The water-based formula is non-staining and leaves no odor, which is a significant advantage for use on mattresses and other indoor areas.

This spray is safe for mattresses but should not be used on pets, ensuring targeted application without harming household items. It's easy to use; simply spray the areas until damp, but avoid saturation, and repeat every two weeks while bed bugs are present. Although the product requires regular application as part of a cycle, it helps achieve effective control over bed bugs. However, the need for frequent reapplication might be considered a drawback for some users.

The spray comes in a large 1-gallon container, making it suitable for extensive treatments. While its weight and size might be cumbersome for some, the ease of use and effectiveness make it a strong choice for those dealing with bed bugs on their mattresses.

The EcoVenger Bed Bug Killer 16 oz spray is a safe and effective option for tackling bed bug infestations on mattresses. Its active ingredients include Geraniol and Cedarwood oil, which are plant-based and non-toxic, making it child and pet safe. You can confidently use it directly on mattresses and box springs without worrying about harmful chemicals.

One notable strength is its effectiveness in killing all life stages of bed bugs, including adults, nymphs, and eggs, even those resistant to traditional pesticides. This is backed by field tests and university studies, ensuring reliable performance. Additionally, it provides extended residual protection for up to two weeks after application, meaning you get lasting results beyond just initial contact. The spray has a cedarwood scent, which might be more pleasant compared to the strong chemical odors found in other products. However, the scent may be a downside for those sensitive to fragrances.

The product's ease of use is also a plus, as it comes in a straightforward spray form, making application simple. Despite these benefits, it’s worth noting that the spray's effectiveness depends on thorough application and might require multiple treatments for severe infestations. Moreover, the product’s volume of 16 fluid ounces may not be sufficient for larger areas, necessitating additional purchases.