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10 Best Cat Urine Enzymatic Cleaner 2025 in the United States

From leading brands and best sellers available on the web.

Sponsored

Rocco & Ro

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Odor Eliminator for Strong Odor - Enzyme Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Enzymatic Cat Urine Destroyer - Carpet Cleaner Spray

#1

Winner

Rocco & Ro

Rocco & Roxie Supply Co.

Editor’s Choice

Rocco & Roxie Supply Co. Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

Sponsored

Rocco & Ro

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Odor Eliminator for Strong Odor - Enzyme Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Enzymatic Cat Urine Destroyer - Carpet Cleaner Spray

#2
Angry Oran

ANGRY ORANGE

Editor’s Choice

Angry Orange Pet Odor Eliminator for Home - 8oz Dog and Cat Pee Smell Remover for Carpet, Grass, Tile and Furniture - Citrus Concentrate, Makes 128oz of Liquid

#3
Angry Oran

ANGRY ORANGE

Editor’s Choice

Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies

#4
Simple Sol

Simple Solution

Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X Pro-Bacteria Cleaning Power | 1 Gallon , 128 Fl Oz (Pack of 1)

#5
Pet Odor a

ACTIVE

Editor’s Choice

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

#6
Nature's M

Nature's Miracle

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

#7
Nature's M

Nature's Miracle

Nature's Miracle Stain and Odor Remover Cat, Odor Control Formula, Pour

#8
BUBBAS Sup

BUBBA'S ROWDY FRIENDS

Editor’s Choice

BUBBAS Super Strength Enzyme Cleaner - Pet Odor Eliminator - Carpet Stain Remover - Remove Dog & Cat Urine Odor from Mattress, Sofa, Rug, Laundry, Hardwood Floors and more. Puppy Training Supplies

#9
Nature's M

Nature's Miracle

Nature's Miracle Advanced Cat Stain and Odor Eliminator Spray, Severe Mess Enzymatic Formula, 32 fl oz

#10
Nature's M

Nature's Miracle

Nature's Miracle Just for Cats Oxy Stain and Odor Remover RED 128 Fl Oz (Pack of 1)

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FAQ

Buying Guide for the Best Cat Urine Enzymatic Cleaner

Choosing the right cat urine enzymatic cleaner is essential for effectively removing stains and odors caused by cat urine. Enzymatic cleaners work by breaking down the proteins in urine, which helps to eliminate the smell and prevent your cat from returning to the same spot. When selecting a cleaner, it's important to consider several key specifications to ensure you get the best product for your needs.
Enzyme FormulaThe enzyme formula is the core component of an enzymatic cleaner. It contains specific enzymes that break down the proteins in cat urine, effectively removing the odor and stain. A strong enzyme formula is crucial for thorough cleaning. Look for products that specifically mention they target cat urine, as these will have the right enzymes for the job. If you have multiple pets or persistent stains, opt for a cleaner with a more concentrated enzyme formula.
Surface CompatibilitySurface compatibility refers to the types of surfaces the cleaner can be used on, such as carpets, upholstery, hardwood floors, and tiles. It's important to choose a cleaner that is safe for the surfaces you need to treat. Some cleaners are versatile and can be used on multiple surfaces, while others are designed for specific materials. If you need to clean various surfaces, a multi-surface cleaner is a good choice. Always check the label to ensure the cleaner won't damage your floors or furniture.
ScentThe scent of the cleaner can affect your overall experience. Some enzymatic cleaners have a strong fragrance to mask the odor of urine, while others are unscented or have a mild scent. If you or your pets are sensitive to strong smells, an unscented or lightly scented cleaner may be preferable. On the other hand, if you want to leave a fresh scent behind, choose a cleaner with a fragrance you find pleasant. Consider your personal preference and any sensitivities when selecting the scent.
Application MethodThe application method refers to how the cleaner is applied to the affected area. Common methods include spray bottles, pour bottles, and foam applicators. Spray bottles are convenient for spot cleaning and small areas, while pour bottles are useful for larger stains. Foam applicators can help the cleaner penetrate deeper into carpets and upholstery. Choose an application method that suits the size and type of the stains you need to treat. For ease of use, a spray bottle is often the most versatile option.
Drying TimeDrying time is the amount of time it takes for the cleaner to dry after application. This can vary depending on the product and the surface being treated. Faster drying times are more convenient, especially if you need to use the area soon after cleaning. However, some cleaners may require a longer drying time to ensure the enzymes fully break down the urine proteins. Consider how quickly you need the area to be usable again and choose a cleaner with an appropriate drying time for your needs.
Eco-FriendlinessEco-friendliness refers to the environmental impact of the cleaner. Eco-friendly enzymatic cleaners are made with biodegradable ingredients and are free from harsh chemicals that can harm the environment. If you are environmentally conscious, look for products labeled as eco-friendly or biodegradable. These cleaners are safer for the environment and often safer for your pets and family as well. Choosing an eco-friendly cleaner can help reduce your environmental footprint while effectively cleaning up cat urine.