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Decongestant Medicines

10 Best Decongestant Medicines 2025 in the United States

Name: Mucinex 12 Hour 1200mg Maximum Strength Guaifenesin Chest Congestion & Mucus Relief, Guaifenesin Expectorant Aids Mucus Removal, Chest Decongestant for Adults, Dr Recommended, 42ct Tablets
Brand: Mucinex
Price: 22.49 USD
Availability: InStock

From leading brands and best sellers available on the web.

Hyland's - Kids - Organic Cough & Immune Day & Night Combo Pack - Eases Coughs, Supports Immunity, Promotes Sleep, Two 4 Fl Oz. Bottles (8 fl oz) (Pack of 2)

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Winner

Mucinex

Mucinex 12 Hour 1200mg Maximum Strength Guaifenesin Chest Congestion & Mucus Relief, Guaifenesin Expectorant Aids Mucus Removal, Chest Decongestant for Adults, Dr Recommended, 42ct Tablets

9.9

score

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Hyland's - Kids - Organic Cough & Immune Day & Night Combo Pack - Eases Coughs, Supports Immunity, Promotes Sleep, Two 4 Fl Oz. Bottles (8 fl oz) (Pack of 2)

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Sudafed

Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct

9.8

score

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Vicks

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

9.8

score

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Tylenol

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

9.7

score

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Hyland's

Editor’s Choice

Hyland's Baby Mucus and Cold Relief, Day & Night Value Pack, Infant And Baby Cold Medicine, Decongestant And Cough Relief, 8 Fl Oz

9.5

score

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GenCare

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

9.3

score

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Mucinex

Mucinex Fast-Max & NightShift Combo Pack - Max Strength Cough & Cold Medicines For Mucus Relief, Chest Congestion, Nasal Congestion, Sinus Congestion, Sinus Pressure, Cough Symptom Relief (2x 6 FL OZ)

9.0

score

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Mucinex

Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

8.8

score

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Mucinex

Mucinex DM Max Liquid Cough & Cold Medicine For Adults, Cold And Flu Medicine for Excess Mucus Relief, Guaifenesin & Dextromethorphan Expectorant & Decongestant for Adults, Dr Recommended, 6.0 Fl Oz

8.6

score

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#10

Coricidin HBP

Coricidin HBP Decongestant-Free Cough and Cold Medicine - Specially Designed Relief for High Blood Pressure, Cough, Runny Nose, Sneezing and Cold Symptoms (16 Count)

8.3

score

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More products we considered

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

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Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu | Compare to Mucinex Tablets (200 Count (Pack of 1))

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HealthA2Z® Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (20 Softgels) (20 Softgels)

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HealthA2Z® Daytime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime(20 Softgels) (Daytime Cold & Flu Medicine (20 Count Pack of 1))

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HealthA2Z® Mucus Relief | Guaifenesin 600 mg | 12 Hour | No Benzene | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus | Extended Release (150 Counts)

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10 Best Decongestant Medicines 2025 in the United States

Hyland's - Kids - Organic Cough & Immune Day & Night Combo Pack - Eases Coughs, Supports Immunity, Promotes Sleep, Two 4 Fl Oz. Bottles (8 fl oz) (Pack of 2)

Mucinex 12 Hour 1200mg Maximum Strength Guaifenesin Chest Congestion & Mucus Relief, Guaifenesin Expectorant Aids Mucus Removal, Chest Decongestant for Adults, Dr Recommended, 42ct Tablets

Hyland's - Kids - Organic Cough & Immune Day & Night Combo Pack - Eases Coughs, Supports Immunity, Promotes Sleep, Two 4 Fl Oz. Bottles (8 fl oz) (Pack of 2)

Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

Hyland's Baby Mucus and Cold Relief, Day & Night Value Pack, Infant And Baby Cold Medicine, Decongestant And Cough Relief, 8 Fl Oz

Hyland's Kids Organic Cough and Immune Day and Night Combo Pack, Eases Coughs, Supports Immunity, Promotes Sleep, Two 4 Fl Oz. Bottles (8 fl oz) (Pack of 2)

Herbion Naturals Respiratory Care Herbal Granules – 10 Ct for The Whole Family – Promotes Healthy Nasal Passages & Respiratory Function - Relieves Cold and Flu Symptoms – Supports Immune System

HealthA2Z® Mucus Relief DM | Dextromethorphan HBr 20mg | Guaifenesin 400mg | No Benzene | Cough, Immediate Release, Uncoated (120 Count (Pack of 1))

HealthA2Z® Mucus Relief | Guaifenesin 1200 mg | NO Benzene |100 Tablets | Maximum Strength | 12 Hour | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus

HealthA2Z® Mucus Relief | Guaifenesin 400mg | Immediate Release | No Benzene | Expectorant (150 Counts)

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

Mucinex Fast-Max & NightShift Combo Pack - Max Strength Cough & Cold Medicines For Mucus Relief, Chest Congestion, Nasal Congestion, Sinus Congestion, Sinus Pressure, Cough Symptom Relief (2x 6 FL OZ)

Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

Mucinex DM Max Liquid Cough & Cold Medicine For Adults, Cold And Flu Medicine for Excess Mucus Relief, Guaifenesin & Dextromethorphan Expectorant & Decongestant for Adults, Dr Recommended, 6.0 Fl Oz

Coricidin HBP Decongestant-Free Cough and Cold Medicine - Specially Designed Relief for High Blood Pressure, Cough, Runny Nose, Sneezing and Cold Symptoms (16 Count)

Decongestants

Mucinex Decongestant Medicines

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Medique Decongestant Medicines

Alka-Seltzer Decongestant Medicines

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu | Compare to Mucinex Tablets (200 Count (Pack of 1))

HealthA2Z® Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (20 Softgels) (20 Softgels)

HealthA2Z® Daytime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime(20 Softgels) (Daytime Cold & Flu Medicine (20 Count Pack of 1))

HealthA2Z® Mucus Relief | Guaifenesin 600 mg | 12 Hour | No Benzene | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus | Extended Release (150 Counts)