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Dog Flea Medicines

10 Best Dog Flea Medicines 2025 in the United States

Name: Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
Brand: Frontline
Price: 31.57 USD
Availability: InStock

From leading brands and best sellers available on the web.

NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Large Dogs, 6 Monthly Doses

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Winner

Frontline

Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

9.9

score

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NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Large Dogs, 6 Monthly Doses

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Frontline

Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

9.8

score

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Frontline

Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

9.6

score

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PetArmor

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

9.3

score

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Capstar

Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

9.1

score

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TevraPet

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Medium Dogs 11-20 lbs | Topical Drops | 4 Months Flea Treatment

8.9

score

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PetArmor

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)

8.6

score

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Frontline

Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

8.3

score

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Veterinary Formula

Veterinary Formula Flea and Tick Spray for Dogs, 8 oz – Easy-to-Use Dog Flea Spray, Kills on Contact, Prevents Egg & Larval Development for 14 weeks

8.1

score

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#10

Advecta

Editor’s Choice

Advecta Ultra Flea And Tick Prevention For Dogs - Dog and Puppy Treatment and Control - Mosquito Repellent - XL, Fast Acting Waterproof Topical Drops, 4 Month Supply

7.8

score

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10 Best Dog Flea Medicines 2025 in the United States

NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Large Dogs, 6 Monthly Doses

Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Large Dogs, 6 Monthly Doses

Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Medium Dogs, 1 Month Dose

Vets Preferred Flea and Tick Prevention for Dogs Chewable - Daily Defense Without Harsh Chemicals - Immune Support & Antioxidant Protection - Beef Flavored - 90 Soft Chews

Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 lbs), 3 Count (Previously Solimo)

Advantus Dog Advantus Chewable Flea Treatment for Dogs 23 - 110 lbs. | 7 ct.

Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Medium Dogs 11-20 lbs | Topical Drops | 4 Months Flea Treatment

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)

Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

Veterinary Formula Flea and Tick Spray for Dogs, 8 oz – Easy-to-Use Dog Flea Spray, Kills on Contact, Prevents Egg & Larval Development for 14 weeks

Advecta Ultra Flea And Tick Prevention For Dogs - Dog and Puppy Treatment and Control - Mosquito Repellent - XL, Fast Acting Waterproof Topical Drops, 4 Month Supply

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