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10 Best Enzyme Drain Cleaners 2025 in the United States

From leading brands and best sellers available on the web.

Sponsored

Drain Fiel

Accelerator by Dr. Pooper

Drain Field Cleaner by Dr. Pooper - Clears Septic System Leach & Drain Field of Clogs & Sludge in 7 to 10 Days - Eliminates Odors & Septic Waste - Keeps Total System Clean, Easy Flush, Fast Dissolving Tablets - Safe for All Systems

#1

Winner

Bioda Prof

Bioda

Bioda Professional Strength Enzyme Drain Cleaner, Septic Safe Drain Odor Eliminator, Drain Smell Eliminator

Sponsored

Drain Fiel

Accelerator by Dr. Pooper

Drain Field Cleaner by Dr. Pooper - Clears Septic System Leach & Drain Field of Clogs & Sludge in 7 to 10 Days - Eliminates Odors & Septic Waste - Keeps Total System Clean, Easy Flush, Fast Dissolving Tablets - Safe for All Systems

#2
Drano Max

Drano

Drano Max Gel Drain Clog Remover and Cleaner for Shower or Sink Drains, Unclogs and Removes Hair, Soap Scum and Blockages, 80 Oz

#3
FRUIT FLY

Green Gobbler

FRUIT FLY GOODBYE Gel Drain Treatment | Drain Fly Killer | Fruit Fly Killer | Drain Flies Treatment | Fruit Flies Treatment | Drain Fly & Fruit Fly Eliminator (1 Gallon)

#4
SANI 360°

SANI 360°

SANI 360° Sani Sticks Drain Cleaner and Deodorizer, Enzyme Pipe Cleaners, Eliminate Odors, Prevent Clogged Drains, Safe for Sinks, Bathtub Drains, Septic Tanks, 24 Count, Lemon Scent

#5
Roebic K-9

Roebic

Roebic K-97 Main Line Cleaner: Exclusive Bacteria Digests Paper, Fats, and Grease in Sewer and Septic Systems - 32 Ounces, Liquid

#6
Quest Spec

Quest Specialty

Quest Specialty DIGEST PLUS Foaming Drain Cleaner and Odor Eliminator, 2 count

#7
Green Gobb

Green Gobbler

Green Gobbler Enzyme Drain Cleaner | Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Lines, Septic Tanks & Grease Traps | 1 Gallon

#8
Green Gobb

Green Gobbler

Green Gobbler Drain Clog Remover | Toilet Clog Remover | Dissolve Hair & Organic Materials from Clogged Toilets, Sinks and Drains | Drain Cleaner and Opener, 128 oz

#9
Green Gobb

Green Gobbler

Green Gobbler Drain Clog Remover & Drain Cleaner Powder (5 Pacs & 5 Tools)

#10
Bio-Ross D

H J Hodes Inc.

Bio-Ross Drain & Septic Drain Cleaner By Bio Ross Elimination Enzyme Drain Cleaner One 2 lbs Containers

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