10 Best Enzyme Pet Cleaner 2025 in the United States

Rocco & Roxie Supply Co. Stain & Odor Eliminator is an enzyme-based cleaner designed specifically for pet-related stains and odors, making it an excellent choice for pet owners dealing with messes from cats and dogs. One of its key strengths is its enzyme-activated formula, which effectively targets and breaks down the organic matter in pet urine, feces, and vomit, ensuring not just the removal of stains but also the elimination of odors. It's certified safe for use around pets and children, as it is chlorine-free and leaves no harmful residues, which is a significant plus for households with little ones or furry friends.

The cleaner is versatile, compatible with multiple surfaces including carpets, floors, and furniture, which adds to its usability. It has a pleasant original scent that helps freshen up areas after cleaning.

However, there are some drawbacks to consider. Some users may find that the drying time can vary, and it might not be as effective on very old or set-in stains. Additionally, while the product claims to work on various surfaces, it is always wise to perform a patch test before using it on delicate materials, as reactions can vary. Lastly, the satisfaction guarantee offered by the company enhances customer confidence in their purchase, although it is limited to purchases from authorized sellers.

The Angry Orange Stain Remover is an enzyme-based cleaner specifically designed to tackle tough pet stains and odors, making it a great option for pet owners dealing with messes from dogs or cats. One of its standout features is the dual-action formula that not only eliminates odors but also destroys stains on contact, providing up to 80 hours of freshness. This capability makes it particularly effective for urine, feces, and vomit, addressing some of the most challenging pet-related cleanups.

The product's versatility is another strong point. It works well on a variety of surfaces, including carpets, hardwood floors, fabric, and turf, which means you can use it throughout your home without worrying about compatibility issues. Plus, the citrus scent from the cold-pressed orange oils leaves a pleasant fragrance, which is a nice bonus for those who dislike chemical smells.

There are some considerations to keep in mind. While the citrus scent is appealing, not everyone may appreciate it, and some people might prefer a fragrance-free option. Safety is also a concern; while it's safe for use around pets and children, it’s essential to avoid direct spraying on them. Lastly, being an enzyme cleaner, it may require some time to work effectively, and users might need to follow specific application methods to achieve the best results.

The AmazonCommercial Multi-Purpose Enzyme Cleaner is a versatile 1-gallon solution designed for tackling a variety of cleaning challenges, particularly in environments that deal with pet-related messes. One of its main strengths is its ability to break down complex organic materials, making it effective against pet stains, odors, and even grease—all common issues in homes with pets or in commercial settings like hotels and restaurants. Its mint scent is a nice touch, providing a fresh smell after cleaning, which can help mask any lingering odors from pets or other sources.

This cleaner is suitable for different surfaces including carpets, drains, and toilets, making it quite adaptable for various applications. Users who manage commercial properties or have large homes with pets will likely find it particularly beneficial.

There are some considerations to keep in mind. While the enzyme-based formula is powerful, it may require multiple applications for tougher stains, which could be a drawback for those looking for a quick fix. Additionally, at 8.6 pounds, the bottle can be somewhat heavy and cumbersome for some users, especially when it's full. Safety is another critical factor, especially for households with pets or children. If you're particularly sensitive to chemicals, it's wise to review ingredient details thoroughly before use. This cleaner is a solid choice for those needing a reliable, multi-surface enzyme cleaner that can handle tough messes, but users should be prepared for the potential need for repeat treatments on stubborn stains.