10 Best Flea And Tick Treatment For Dogs 2025 in the United States

The Seresto Large Dog Flea & Tick Treatment & Prevention Collar is a highly reputable choice for dogs over 18 pounds, recommended by veterinarians. It's designed to offer up to 8 months of continuous protection by killing and repelling fleas and ticks through contact, meaning pests don't need to bite your dog to be affected.

This collar is non-greasy and easy to apply, making it a hassle-free option for pet owners. The active ingredients, Imidacloprid and Flumethrin, start working within 24 hours, providing quick relief for your pet. It's suitable for dogs aged 7 weeks and older, so it can be used on puppies as well. However, the product must be periodically adjusted, especially for growing pups to ensure a snug fit.

The collar is unscented and allergen-free, which is advantageous for dogs with sensitivities. On the downside, some dogs might experience mild side effects like skin irritation. While relatively expensive, its long-lasting nature could justify the cost over time. It's a practical choice for large dog owners looking for an effective, low-maintenance flea and tick solution.

PetArmor Plus Flea and Tick Prevention for Dogs is a waterproof, topical treatment designed for large dogs weighing between 45-88 lbs. With active ingredients fipronil and (S)-methoprene, the same as those found in the trusted FRONTLINE Plus, this product effectively kills fleas, flea eggs, flea larvae, ticks, and chewing lice. One of its key strengths is its ability to break the flea life cycle, which helps prevent re-infestation.

Each application remains effective for up to 30 days, and with a pack of six doses, your dog is covered for about six months. The product is fast-acting, starting to kill fleas within 24 hours of application, and is suitable for all life stages of large dog breeds. Applying it is straightforward: the solution is applied between the dog's shoulder blades, and it dries completely in about 24 hours. However, some users might find the greasy residue left on the fur post-application an inconvenience.

It's worth noting that you need to keep treated pets away from other pets and children until the product has dried. While generally safe, some dogs may experience side effects, such as mild skin irritation or temporary discomfort. This product is suitable for large dogs and owners looking for a long-lasting, easy-to-use solution for flea and tick prevention.

FRONTLINE Plus Flea and Tick Treatment for Large Dogs offers a topical solution that effectively combats fleas, ticks, flea eggs, flea larvae, and chewing lice. The treatment is waterproof, ensuring continuous protection even if your dog gets wet. It uses fipronil and (S)-methoprene as active ingredients, which are well-regarded for breaking the flea life cycle and preventing further infestations. This can provide peace of mind for up to 30 days per application, making it suitable for monthly use.

The treatment can be applied to dogs weighing between 45 and 88 pounds and is safe for puppies as young as eight weeks old, which broadens its usability across different life stages and sizes of dogs. Application is straightforward with a stick form, making it easy for pet owners to administer. On the downside, some dogs may experience side effects such as skin irritation or allergic reactions, although this isn't common.

Additionally, while the product is unscented, some pets might still dislike the application process. The subscription option makes it convenient to maintain regular protection without running out of doses. This treatment is trusted by pet owners for over 20 years, making it a reliable option for comprehensive flea and tick control.