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10 Best Flea Killers 2025 in the United States

From leading brands and best sellers available on the web.

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NEXTSTAR F

NEXTSTAR

17%OFF

NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Small Dogs, 6 Monthly Doses

#1

Winner

Advantage

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

Sponsored

NEXTSTAR F

NEXTSTAR

17%OFF

NEXTSTAR Flea and Tick Prevention for Dogs, Repellent, and Control, Fast Acting Waterproof Topical Drops for Small Dogs, 6 Monthly Doses

#2
PetArmor P

PetArmor

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)

#3
Frontline

Frontline

Frontline Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

#4
Frontline

Frontline

Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

#5
Frontline

Frontline

Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

#6
Capstar (n

Capstar

Capstar (nitenpyram) for Dogs, Fast-Acting Oral Flea Treatment for Dogs over 25+ lbs, Vet-Recommended Flea Medication Tablets Start Killing Fleas in 30 Minutes, 6 Doses

#7
Ortho Home

Ortho

Ortho Home Defense Max Indoor Insect Barrier: Starts to Kill Ants, Roaches, Spiders, Fleas & Ticks Fast, 1 gal.

#8
Activate I

TevraPet

Activate II Flea and Tick Prevention for Dogs | 4 Count | Large Dogs 21-55 lbs | Topical Drops | 4 Months Flea Treatment

#9
Frontline

Frontline

Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

#10
PetArmor C

PetArmor

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)

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