10 Best Hydrocortisone Creams 2025 in the United States

CeraVe 1% Hydrocortisone Anti-Itch Cream is a solid choice for anyone dealing with extra dry skin or eczema-related discomfort. With its maximum strength of 1% hydrocortisone, it effectively offers itch relief without needing a prescription. This cream is also designed to be gentle on sensitive skin, as it holds the National Eczema Association’s Seal of Acceptance and is fragrance-free, which helps avoid irritation for those who may have allergies or sensitivities.

One of the standout strengths of this product is its hydrating properties. It includes essential ingredients like Hyaluronic Acid, which helps the skin retain moisture, and Niacinamide, known for its soothing effects. Additionally, the inclusion of three essential ceramides aids in restoring and maintaining the skin’s natural barrier, making this cream a good option not just for treating symptoms but also for supporting skin health.

While the cream offers many benefits, there are a few considerations to keep in mind. Users may find that the application frequency can be a bit tricky; although it's meant for use as needed, some may need to apply it multiple times a day for maximum relief. Furthermore, while the cream is designed for minor irritations and rashes, it may not be as effective for more severe skin conditions, and prolonged use should be approached cautiously.

The Amazon Basic Care Maximum Strength Anti-Itch Cream is a solid option for those suffering from itching due to various skin issues like bug bites, eczema, psoriasis, and poison ivy. One of its standout strengths is the active ingredient, hydrocortisone 1 percent, which is widely recommended by doctors for its effectiveness in relieving itchiness and skin inflammation. Its maximum strength formula provides relief that can last up to 10 hours, making it convenient for users needing consistent itch control throughout the day.

The cream also features a hydrating, intensive healing formula that includes antioxidants and vitamins A, C, and E, which can be beneficial for those looking for additional skin nourishment. The inclusion of chamomile is a nice touch, as it may help soothe irritated skin. Importantly, it is safe for both adults and children aged two and older, which broadens its usability.

On the downside, while the cream effectively targets itch and irritation, some users may find that it takes time to fully absorb, which could be a concern for those seeking a quick, non-greasy application. Additionally, as with any topical treatment, it is essential to follow the application frequency and duration guidelines to avoid potential side effects from prolonged use. Some individuals may also be sensitive to certain ingredients, so a patch test is advisable before widespread application.

The Cortizone 10 Maximum Strength Intensive Moisture Anti-Itch Cream is a strong contender in the hydrocortisone cream category, offering 1% hydrocortisone which is the highest non-prescription strength available. This makes it highly effective for quick relief from minor skin irritations, such as bug bites, rashes, eczema, psoriasis, and poison ivy. The cream acts fast, reportedly providing itch relief in under 10 minutes and lasting for several hours, which is a significant benefit for those needing quick and lasting comfort.

Additionally, the product is enriched with seven moisturizers and vitamins A, C, and E, ensuring that the skin stays hydrated and nourished, which is great for those with dry or chapped skin. It is also fragrance-free and dye-free, making it suitable for sensitive skin and gentle enough for daily use. As the #1 Doctor-Recommended OTC Anti-Itch Brand, it has a strong endorsement from healthcare professionals.

The product comes in a small 1 oz. tube, which might not last long for frequent users or those with larger areas to treat. While effective for minor irritations, it may not be suitable for more severe skin conditions that require prescription-strength medication. Cortizone 10 is an excellent option for those needing fast, moisturizing itch relief for minor skin issues, but its small size and potency limits should be considered.