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10 Best Lubricant Eye Drops 2025 in the United States

From leading brands and best sellers available on the web.
#1

Winner

Refresh Op

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

#2
Systane CO

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

#3
Refresh Te

Refresh

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

#4
Systane Ul

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

#5
OCuSOFT Re

OCuSOFT

OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz

#6
TheraTears

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

#7
iVIZIA Ste

iVIZIA

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz Bottle

#8
Refresh Pl

Refresh

Refresh Plus Lubricant Eye Drops, Preservative Free, Single Use Containers, 30 Count

#9
Systane Ul

Systane

Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)

#10
Refresh Op

Refresh

Refresh Optive Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count

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