10 Best Otc Decongestants 2025 in the United States

Vicks Sinex SEVERE Nasal Spray is an effective over-the-counter decongestant designed to provide relief from nasal congestion and sinus pressure due to colds or allergies. The key strength of this product lies in its powerful formulation, which delivers the active decongestant directly to the nasal membranes for quick action.

Users can expect significant relief for up to 12 hours, making it a convenient option for both day and night use. It is important to note that this product is not intended for daily use due to potential side effects common with nasal sprays, such as nasal dryness or irritation.

Its compact size and large number of sprays (265) per bottle add to its convenience. This product may be particularly beneficial for those experiencing severe sinus congestion and pressure who need immediate and long-lasting relief.

Sudafed PE Sinus Congestion Maximum Strength is a non-drowsy decongestant with 36 tablets designed to provide relief from sinus pressure and nasal congestion. Each tablet contains 10 mg of phenylephrine HCI, a common nasal decongestant. This formulation is effective in helping to temporarily relieve nasal congestion due to hay fever, upper respiratory allergies, and the common cold. Its non-drowsy nature makes it suitable for use during the day without interfering with daily activities or causing drowsiness.

Users are advised to take one tablet every 4 hours, with a maximum of 6 tablets in 24 hours, making it a practical option for those needing consistent relief throughout the day. The product is suitable for adults and children aged 12 and above. Being pharmacist-recommended adds to its credibility and trustworthiness among oral OTC decongestants. A notable strength is its fast-acting formula, which can quickly alleviate symptoms.

However, like all medications, it may have side effects, and some users might experience reactions to phenylephrine. Additionally, it does not provide a combination of other medicinal benefits like some multi-symptom cold medications, which could be a limitation for those looking for an all-in-one solution. Sudafed PE is a reliable option for those seeking targeted relief from sinus and nasal congestion without the drowsiness associated with some other decongestants.

Claritin 24hr Non-Drowsy Allergy Relief is a convenient option for those seeking relief from allergy symptoms without a prescription. Each tablet contains 10 mg of Loratadine, an antihistamine that blocks the effects of histamines, providing relief from symptoms like sneezing, runny nose, itchy/watery eyes, and itchy throat/nose. The pack includes 31 tablets, which is ideal for a month's supply of daily, 24-hour, non-drowsy relief from both indoor and outdoor allergens such as pollen, dust, mold, and pet dander.

Its non-drowsy formulation allows you to carry on with your day without feeling sleepy, which is a significant advantage for those with active lifestyles. Additionally, being the #1 doctor-recommended non-drowsy oral allergy brand adds credibility to its effectiveness. However, some users might experience side effects, though they are generally mild, such as headache or dry mouth. The product's compact packaging makes it easy to carry, which is beneficial for those who need relief on-the-go.

This product is suitable for individuals looking for a reliable, long-lasting, and non-drowsy allergy relief solution.