10 Best Otc Decongestants 2025 in the United States

Vicks Sinex SEVERE Nasal Spray is an effective over-the-counter decongestant designed to provide relief from nasal congestion and sinus pressure due to colds or allergies. The key strength of this product lies in its powerful formulation, which delivers the active decongestant directly to the nasal membranes for quick action.

Users can expect significant relief for up to 12 hours, making it a convenient option for both day and night use. It is important to note that this product is not intended for daily use due to potential side effects common with nasal sprays, such as nasal dryness or irritation.

Its compact size and large number of sprays (265) per bottle add to its convenience. This product may be particularly beneficial for those experiencing severe sinus congestion and pressure who need immediate and long-lasting relief.

Claritin 24hr Non-Drowsy Allergy Relief is a convenient option for those seeking relief from allergy symptoms without a prescription. Each tablet contains 10 mg of Loratadine, an antihistamine that blocks the effects of histamines, providing relief from symptoms like sneezing, runny nose, itchy/watery eyes, and itchy throat/nose. The pack includes 31 tablets, which is ideal for a month's supply of daily, 24-hour, non-drowsy relief from both indoor and outdoor allergens such as pollen, dust, mold, and pet dander.

Its non-drowsy formulation allows you to carry on with your day without feeling sleepy, which is a significant advantage for those with active lifestyles. Additionally, being the #1 doctor-recommended non-drowsy oral allergy brand adds credibility to its effectiveness. However, some users might experience side effects, though they are generally mild, such as headache or dry mouth. The product's compact packaging makes it easy to carry, which is beneficial for those who need relief on-the-go.

This product is suitable for individuals looking for a reliable, long-lasting, and non-drowsy allergy relief solution.

The Major 12-Hour Nasal Decongestant Spray uses Oxymetazoline Hydrochloride 0.05% as its active ingredient, which is known for effectively reducing nasal congestion. This formulation is designed for both adults and kids (aged 6 to under 12 with adult supervision), making it a versatile option for family use. The spray is easy to use with a soothing pump mist, and it offers long-lasting relief for up to 12 hours, which means you won't need to reapply frequently throughout the day.

It is crucial to note that this spray should not be used more than twice in a 24-hour period and not for more than three consecutive days to avoid the risk of rebound congestion (where nasal congestion worsens instead of improving). The product does not mention any combination with other ingredients to address multiple symptoms simultaneously, so it focuses solely on nasal decongestion. There are no specific side effects listed, but users should be aware that overuse can cause issues.

This spray could be a great option for those dealing with temporary nasal congestion due to colds, allergies, or sinus pressure, as long as they follow the usage instructions carefully.