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Skin Care

Over The Counter Acne Spot Treatment

10 Best Over The Counter Acne Spot Treatment 2025 in the United States

Name: Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
Brand: Differin
Price: 26.47 USD
Availability: InStock

From leading brands and best sellers available on the web.

iRestore LED Face Mask Light Therapy | Blue, Infrared & Red Light Therapy for Face | Illumina Skincare Device Facemask - Youthful Radiant Skin with Reduced Wrinkles, Fine Lines | Contour | 360 LEDs

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Winner

Differin

Editor’s Choice

Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)

9.8

score

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iRestore LED Face Mask Light Therapy | Blue, Infrared & Red Light Therapy for Face | Illumina Skincare Device Facemask - Youthful Radiant Skin with Reduced Wrinkles, Fine Lines | Contour | 360 LEDs

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Mario Badescu

Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz

9.6

score

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Peach Slices

Peach Slices | Deep Blemish Microdarts | Acne Patch | Early Stage & Deep Pimples | Fast-Acting | Salicylic Acid | Tea Tree Oil | Niacinamide | Cica | Hyaluronic Acid | Spot Treatment | 9 Patches

9.3

score

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CeraVe

CeraVe Acne Control Gel, 2% Salicylic Acid Acne Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Acne Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

9.0

score

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Murad

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

8.7

score

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Kate Somerville

Kate Somerville EradiKate Acne Treatment - Clinically Formulated 10% Sulfur and BHA Spot Treatment – Clears Pimples, Cleans Pores and Prevents Breakouts, 1 Fl Oz

8.4

score

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Proactiv

Proactiv Emergency Blemish Relief - Benzoyl Peroxide Gel - Acne Spot Treatment for Face and Body, .33 Oz

8.1

score

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Amazon Basics

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

7.8

score

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Kiehl's

Kiehl's Truly Targeted Acne-Clearing Pimple Patch with 2% Salicylic Acid, Invisible Liquid Acne Spot Treatment, 4% Niacinamide Fades Post-acne Marks, 0.2% Licorice Root Soothes Redness - 0.5 fl oz

7.5

score

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#10

La Roche-Posay

La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment for Acne and Blackheads, Lightweight Sheerness, Safe For Sensitive Skin ,0.7 Fl Oz

7.2

score

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More products we considered

By Nature Bee Venom Face Mask for Anti-Aging, Wrinkle Reduction, and Skin Tightening - 1oz (30ml)

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NURIVE Invisible Face Lift Tape (80 Tapes) | Collagen Face Lift Tape Invisible | Face Tape for Wrinkles with Jojoba Oil | Forehead Wrinkle Patches for Face Saggy Skin | Face Lifting Bands

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NURIVE Forehead Wrinkle Patches 20ct | Invisible Anti Wrinkle Patches for Forehead Wrinkles, Collagen Infused Korean Skin Care OvernightTreatment - Forehead Patches with Retinol & Hyaluronic Acid

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NURIVE Advanced Wrinkle Patches 60ct | Smile Line, Frown Line Wrinkle Patches | Wrinkle Patches for Facial Korean Skin Care | Face Wrinkle Tape Invisible Overnight with Retinol & Collagen

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Tiege Hanley Mens Detoxifying Facial Clay Mask, 2 Oz (2-Pack) - Deep Pore Cleansing Charcoal Face Mask with Natural Kaolin Clay Absorbs Excess Oil & Reduces Appearance Pores - Skin Care for Men

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How do we rank products for you?

Our technology thoroughly searches through the online shopping world, reviewing hundreds of sites. We then process and analyze this information, updating in real-time to bring you the latest top-rated products. This way, you always get the best and most current options available.

10 Best Over The Counter Acne Spot Treatment 2025 in the United States

iRestore LED Face Mask Light Therapy | Blue, Infrared & Red Light Therapy for Face | Illumina Skincare Device Facemask - Youthful Radiant Skin with Reduced Wrinkles, Fine Lines | Contour | 360 LEDs

Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)

iRestore LED Face Mask Light Therapy | Blue, Infrared & Red Light Therapy for Face | Illumina Skincare Device Facemask - Youthful Radiant Skin with Reduced Wrinkles, Fine Lines | Contour | 360 LEDs

Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz

Peach Slices | Deep Blemish Microdarts | Acne Patch | Early Stage & Deep Pimples | Fast-Acting | Salicylic Acid | Tea Tree Oil | Niacinamide | Cica | Hyaluronic Acid | Spot Treatment | 9 Patches

CeraVe Acne Control Gel, 2% Salicylic Acid Acne Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Acne Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

Baebody Snail Mucin Mask (6 pcs) - Hydrating Face Mask Sheet with Hyaluronic Acid - Moisturizing Face Mask for Youthful Skin - Korean Face Mask Inspired - Anti Aging Face Masks Skincare Korean

CSM Caviar & Pearl Face Mask – Luminous Hydrated Skin – Reduces Fine Lines & Wrinkles, Brightens Complexion, and Strengthens Skin Barrier – 5 Individually-Wrapped Masks

By Nature 2 in 1 Pore Purifying Face Cleanser and Mask with Green Tea and Activated Charcoal

By Nature Brightening Pink Clay Face Mask and Brush 60g

By Nature Hydro Jelly Sleep Mask with Glycerin, Aloe Vera and Hyaluronic Acid

Kate Somerville EradiKate Acne Treatment - Clinically Formulated 10% Sulfur and BHA Spot Treatment – Clears Pimples, Cleans Pores and Prevents Breakouts, 1 Fl Oz

Proactiv Emergency Blemish Relief - Benzoyl Peroxide Gel - Acne Spot Treatment for Face and Body, .33 Oz

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

Kiehl's Truly Targeted Acne-Clearing Pimple Patch with 2% Salicylic Acid, Invisible Liquid Acne Spot Treatment, 4% Niacinamide Fades Post-acne Marks, 0.2% Licorice Root Soothes Redness - 0.5 fl oz

La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment for Acne and Blackheads, Lightweight Sheerness, Safe For Sensitive Skin ,0.7 Fl Oz

Over The Counter Toe Fungus Treatment

Poison Ivy Over The Counter Treatments

Over The Counter Cold Sore Treatment

Acne Spot Treatments

By Nature Bee Venom Face Mask for Anti-Aging, Wrinkle Reduction, and Skin Tightening - 1oz (30ml)

NURIVE Invisible Face Lift Tape (80 Tapes) | Collagen Face Lift Tape Invisible | Face Tape for Wrinkles with Jojoba Oil | Forehead Wrinkle Patches for Face Saggy Skin | Face Lifting Bands

NURIVE Forehead Wrinkle Patches 20ct | Invisible Anti Wrinkle Patches for Forehead Wrinkles, Collagen Infused Korean Skin Care OvernightTreatment - Forehead Patches with Retinol & Hyaluronic Acid

NURIVE Advanced Wrinkle Patches 60ct | Smile Line, Frown Line Wrinkle Patches | Wrinkle Patches for Facial Korean Skin Care | Face Wrinkle Tape Invisible Overnight with Retinol & Collagen

Tiege Hanley Mens Detoxifying Facial Clay Mask, 2 Oz (2-Pack) - Deep Pore Cleansing Charcoal Face Mask with Natural Kaolin Clay Absorbs Excess Oil & Reduces Appearance Pores - Skin Care for Men