10 Best Pain Relief For Toothache 2025 in the United States

The Orajel Maximum Strength Nighttime Toothache Pain Relief Cream is designed specifically to provide relief from toothache pains. Its active ingredient, Benzocaine, is a powerful anesthetic that effectively numbs the affected area, offering significant pain relief. The cream form allows easy application directly to the sore spot, ensuring the medicine is applied precisely where it’s needed most.

This product is particularly useful for nighttime use, providing relief that can help you sleep through the night. However, the duration of relief can vary, and it may not last all night for everyone, potentially requiring reapplication. Some users may find the small size of the tube convenient for storage and travel, but it might also mean the product runs out quickly if used frequently.

Ease of use is generally high, though applying it directly to the affected area requires some care to avoid touching other parts of the mouth. As with any medicinal product, there are potential side effects, including allergic reactions or irritation for some users. It is advisable to conduct a patch test before full application. This cream is a practical option for those dealing with tooth pain and seeking an over-the-counter remedy, but it is best used as a temporary solution while awaiting professional dental care.

The DenTek Instant Oral Pain Relief Maximum Strength Kit is designed to provide quick and targeted relief from toothaches and other oral pains. The product contains Benzocaine (20%), a powerful active ingredient known for its efficacy in numbing pain. It comes in a convenient kit form, which includes 50 disposable applicators, an ergonomic handle, and a carrying case, making it easy to use and hygienic. The ergonomic handle helps you apply the medication precisely without making a mess, ensuring that you can reach any part of your mouth comfortably.

The product also features a fresh mint flavor, which can make the application more pleasant. However, it is important to note that the relief provided by Benzocaine is temporary, so it may require reapplication if the pain persists. Additionally, while the mint flavor is a nice touch, some users might be sensitive to the taste or the active ingredient itself, leading to potential side effects such as irritation or allergic reactions. The kit's design, with its multiple applicators and case, makes it perfect for on-the-go use, offering convenience and portability.

This product is best suited for individuals who need immediate, short-term relief from toothaches and other minor oral pains. It is user-friendly, sanitary, and provides effective pain relief, but users should be mindful of the temporary nature of the relief and potential side effects. Those looking for a long-term solution or who have severe pain might need to consult a dentist for more comprehensive treatment.

Anbesol Maximum Strength Oral Pain Relief Gel is designed to offer instant relief for various types of oral pain, including toothaches, canker sores, sore gums, denture pain, and irritation from dental procedures. The active ingredient is Benzocaine 20%, which provides maximum strength pain relief.

The product is easy to use; simply cut the tube tip to access the gel, and it is suitable for adults and children over 2 years old. However, it should not be used on children under 2 years of age. The product is well-regarded and ADA accepted, ensuring it meets certain dental standards.

One of the main benefits is the immediate relief it offers, making it a convenient option for those suffering from sudden or severe oral pain. On the downside, some users may experience side effects from Benzocaine, which can include allergic reactions or irritation. The small tube (0.33 oz) might also run out quickly if used frequently. This product is best suited for individuals who need quick, temporary relief from oral pain but should be used with caution in case of sensitivity to the active ingredient.