10 Best Pain Relief For Toothache 2025 in the United States

The DenTek Instant Oral Pain Relief Maximum Strength Kit is designed to provide quick and targeted relief from toothaches and other oral pains. The product contains Benzocaine (20%), a powerful active ingredient known for its efficacy in numbing pain. It comes in a convenient kit form, which includes 50 disposable applicators, an ergonomic handle, and a carrying case, making it easy to use and hygienic. The ergonomic handle helps you apply the medication precisely without making a mess, ensuring that you can reach any part of your mouth comfortably.

The product also features a fresh mint flavor, which can make the application more pleasant. However, it is important to note that the relief provided by Benzocaine is temporary, so it may require reapplication if the pain persists. Additionally, while the mint flavor is a nice touch, some users might be sensitive to the taste or the active ingredient itself, leading to potential side effects such as irritation or allergic reactions. The kit's design, with its multiple applicators and case, makes it perfect for on-the-go use, offering convenience and portability.

This product is best suited for individuals who need immediate, short-term relief from toothaches and other minor oral pains. It is user-friendly, sanitary, and provides effective pain relief, but users should be mindful of the temporary nature of the relief and potential side effects. Those looking for a long-term solution or who have severe pain might need to consult a dentist for more comprehensive treatment.

The Orajel Maximum Strength Nighttime Toothache Pain Relief Cream is designed specifically to provide relief from toothache pains. Its active ingredient, Benzocaine, is a powerful anesthetic that effectively numbs the affected area, offering significant pain relief. The cream form allows easy application directly to the sore spot, ensuring the medicine is applied precisely where it’s needed most.

This product is particularly useful for nighttime use, providing relief that can help you sleep through the night. However, the duration of relief can vary, and it may not last all night for everyone, potentially requiring reapplication. Some users may find the small size of the tube convenient for storage and travel, but it might also mean the product runs out quickly if used frequently.

Ease of use is generally high, though applying it directly to the affected area requires some care to avoid touching other parts of the mouth. As with any medicinal product, there are potential side effects, including allergic reactions or irritation for some users. It is advisable to conduct a patch test before full application. This cream is a practical option for those dealing with tooth pain and seeking an over-the-counter remedy, but it is best used as a temporary solution while awaiting professional dental care.

Orajel 2X Medicated Toothache & Mouth Sores Liquid is designed to provide quick relief for oral pain and discomfort. It contains 20% Benzocaine, which is a powerful anesthetic for numbing pain, and menthol to soothe the gums. The liquid form allows for fast-acting relief, which is ideal when dealing with sudden toothache or mouth sores.

This product is particularly beneficial for those needing immediate pain relief and is easy to apply directly to the affected area. As the #1 Oral Pain Reliever Brand for Toothache, it is a trusted option for many users. The 2X formula means it has twice as many active ingredients as single medicated products, potentially offering more effective relief.

However, it’s important to remember that such strong medication can have side effects, including possible allergic reactions or temporary burning/stinging sensations. The duration of relief varies among users, and it may not provide long-term relief without reapplication. Manufactured by Church & Dwight and available since 2011, the product has established a good reputation in the market. The compact size makes it easy to carry around, but be cautious about overuse as it could lead to side effects associated with Benzocaine.