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10 Best Prescription Wrinkle Cream 2025 in the United States

From leading brands and best sellers available on the web.

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Paula's Ch

Paula's Choice

15%OFF

Paula's Choice SKIN PERFECTING 2% BHA Liquid Salicylic Acid Exfoliant-Facial Exfoliant for Blackheads, Enlarged Pores, Wrinkles & Fine Lines

#1

Winner

Paula's Ch

Paula's Choice

Paula's Choice CLINICAL 1% Retinol Treatment Cream with Peptides, Vitamin C & Licorice Extract, Anti-Aging & Wrinkles, Travel Size. PACKAGING MAY VARY.

Sponsored

Paula's Ch

Paula's Choice

15%OFF

Paula's Choice SKIN PERFECTING 2% BHA Liquid Salicylic Acid Exfoliant-Facial Exfoliant for Blackheads, Enlarged Pores, Wrinkles & Fine Lines

#2
RoC Retino

RoC

RoC Retinol Correxion Under Eye Cream for Dark Circles & Puffiness, Daily Wrinkle Cream, Anti Aging Line Smoothing Skin Care Treatment for Women and Men, 0.5 oz (Packaging May Vary)

#3
Neutrogena

Neutrogena

Neutrogena Retinol Face Moisturizer, Rapid Wrinkle Repair, Daily Anti-Aging Face Cream with Retinol & Hyaluronic Acid to Fight Fine Lines, Wrinkles, & Dark Spots, 1.7 oz

#4
Retinol Cr

MOONRIN COSMETICS

Retinol Cream for Face with Hyaluronic Acid - Anti Aging Wrinkle Cream for Women, Collagen Face Moisturizer for Firm Skin, Day & Night Care, 1.85 Oz

#5
RoC Retino

RoC

RoC Retinol Correxion Max Daily Hydration Anti-Aging Face Moisturizer with Hyaluronic Acid, Oil Free Skin Care Cream for Fine Lines, Dark Spots, Post-Acne Scars, 1.7 Ounces (Packaging May Vary)

#6
LilyAna Na

LilyAna Naturals

Editor’s Choice

LilyAna Naturals Retinol Cream - Made in USA, Anti Aging Moisturizer for Face and Neck,Wrinkle, Retinol Complex - 1.7oz

#7
RoC Retino

RoC

RoC Retinol Correxion Deep Wrinkle Retinol Face Serum with Ascorbic Acid, Daily Anti-Aging Skin Care Treatment for Fine Lines, Dark Spots, Acne Scars, 1 Ounce (Packaging May Vary)

#8
Neutrogena

Neutrogena

Neutrogena Retinol Eye Cream for Dark Circles, Rapid Wrinkle Repair, Daily Anti-Aging Under Eye Cream with Retinol & Hyaluronic Acid to Fight Fine Lines, Wrinkles, & Dark Spots, 0.5 fl. oz

#9
RoC Retino

RoC

RoC Retinol Correxion Deep Wrinkle Facial Filler with Hyaluronic Acid & Retinol, Skin Care for Women and Men, 1 Fl Oz (Packaging May Vary)

#10
RoC Retino

RoC

RoC Retinol Correxion Deep Wrinkle Anti-Aging Night Cream, Daily Face Moisturizer with Shea Butter, Glycolic Acid and Squalane, Skin Care Treatment, 1 Ounces (Packaging May Vary)

More products we considered

Glycolic Acid Peel AHA BHA Exfoliant - 70% USP Grade Clinical Strength Age-Defying At Home Chemical Peel For Face - Salicylic & Lactic Acid Peel- Rejuvenating Aloe Vera, Manuka Honey & Hyaluronic Acid

Glycolic Acid Peel AHA BHA Exfoliant - 70% USP Grade Clinical Strength Age-Defying At Home Chemical Peel For Face - Salicylic & Lactic Acid Peel- Rejuvenating Aloe Vera, Manuka Honey & Hyaluronic Acid

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Elvira Korean Skincare Anti-Aging & Glycolic Acid Exfoliating Facial Pads With 10% Glycolic Acid, 2% Salicylic Acid & Niacinamide - 60 Toner Pads, Daily Peel Treatment for Acne Prone Sensitive Skin

Elvira Korean Skincare Anti-Aging & Glycolic Acid Exfoliating Facial Pads With 10% Glycolic Acid, 2% Salicylic Acid & Niacinamide - 60 Toner Pads, Daily Peel Treatment for Acne Prone Sensitive Skin

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Pacifica Beauty Glow Baby Brightening Peel Pads 10% AHA + BHA, Skincare, Exfoliating, Skin Texture, Minimize Pores, For All Skin Types, Fragrance Free, Clean Skin Care, Vegan - 60 Pads (1 Count)

Pacifica Beauty Glow Baby Brightening Peel Pads 10% AHA + BHA, Skincare, Exfoliating, Skin Texture, Minimize Pores, For All Skin Types, Fragrance Free, Clean Skin Care, Vegan - 60 Pads (1 Count)

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Envy Hyaluronic & Salicylic Acid Face Moisturizer Cream - Hydrating, Acne Scar Reduction & Anti-Aging Day Cream - Dermatologist Tested, Clean Beauty for All Skin Types - 1.69 Fl. Oz

Envy Hyaluronic & Salicylic Acid Face Moisturizer Cream - Hydrating, Acne Scar Reduction & Anti-Aging Day Cream - Dermatologist Tested, Clean Beauty for All Skin Types - 1.69 Fl. Oz

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Pacifica Beauty | Glow Baby Liquid Exfoliant 5% AHA + BHA | Glycolic, Lactic & Salicylic Acid | Toner | Glowing Skin Finish | Clear Pores | Smooths, Brightens, & Tones Skin | Vegan + Cruelty Free

Pacifica Beauty | Glow Baby Liquid Exfoliant 5% AHA + BHA | Glycolic, Lactic & Salicylic Acid | Toner | Glowing Skin Finish | Clear Pores | Smooths, Brightens, & Tones Skin | Vegan + Cruelty Free

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Our technology thoroughly searches through the online shopping world, reviewing hundreds of sites. We then process and analyze this information, updating in real-time to bring you the latest top-rated products. This way, you always get the best and most current options available.

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