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Beauty & Personal Care

Skin Care

Spot Treatments

10 Best Spot Treatments 2025 in the United States

Name: Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)
Brand: Mighty Patch
Price: 12.99 USD
Availability: InStock

From leading brands and best sellers available on the web.

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

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Winner

Mighty Patch

Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)

9.7

score

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Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

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Differin

Editor’s Choice

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

9.4

score

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Mario Badescu

Mario Badescu AM/PM Blemish Kit, Includes Drying Lotion Spot Treatment with Salicylic Acid and Sulfur (1 Fl Oz) AND Drying Patch Facial Stickers, Invisible Pimple Patches (12 Count)

9.2

score

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Murad

Murad Deep Relief Acne Treatment - Acne Control Max Strength 2% Salicylic Acid, Healing Treatment for Deep, Uncomfortable Acne, 1 Fl Oz

8.9

score

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AXIS-Y

AXIS-Y Dark Spot Correcting Glow Serum 50ml / 1.69 fl. oz | Brightening Serum | Korean Skincare, Dark Spot Treatment, Hyperpigmentation Treatment

8.6

score

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Murad

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

8.3

score

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Proactiv

Proactiv Emergency Blemish Relief - Benzoyl Peroxide Gel - Acne Spot Treatment for Face and Body, .33 Oz

8.0

score

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Amazon Basics

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

7.7

score

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La Roche-Posay

La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment for Acne and Blackheads, Lightweight Sheerness, Safe For Sensitive Skin ,0.7 Fl Oz

7.4

score

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#10

Neutrogena

Neutrogena Stubborn Acne Spot Drying Lotion, Fragrance-Free Sulfur Acne Treatment Clears Acne By Drying Up & Shrinking Pimples, Paraben- & Oil-Free, 10% Sulfur & 4% Niacinamide, 1.0 fl. oz

7.1

score

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10 Best Spot Treatments 2025 in the United States

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

Mario Badescu AM/PM Blemish Kit, Includes Drying Lotion Spot Treatment with Salicylic Acid and Sulfur (1 Fl Oz) AND Drying Patch Facial Stickers, Invisible Pimple Patches (12 Count)

Murad Deep Relief Acne Treatment - Acne Control Max Strength 2% Salicylic Acid, Healing Treatment for Deep, Uncomfortable Acne, 1 Fl Oz

AXIS-Y Dark Spot Correcting Glow Serum 50ml / 1.69 fl. oz | Brightening Serum | Korean Skincare, Dark Spot Treatment, Hyperpigmentation Treatment

Goldfaden MD Needle-Less Line Smoothing Concentrate for Face & Neck | w/Seaweed Extract, Hyaluronic Acid, Hexapeptides, Organic Red Tea Extract 1 Ounce

Aloe Up White Collection Sunscreen Lotion SPF 50 - Broad Spectrum UVA/UVB Sunscreen Protector for Face and Body - With Aloe Vera Gel - Alcohol-Free - Reef Friendly - Coco-Mango Fragrance - 4 Oz

Tree of Life Beauty Anti-Aging Eye Treatment Gel Cream to Hydrate Dark Circles and Reduce Puffiness, Bags and Wrinkles, Vitamin C

Skincare Tightening Neck Therapy Cream for Face | Anti-Aging Lotion | Helps to Firm & Tighten Loose Sagging Skin Smooth Wrinkles & Fine Lines | More Youthful Neck and Chest | 2 fl oz/60 ml

Tree of Life Beauty Retinol Serum, Skin Smoothing Face Oil for Dark and Age Spots and Fine Lines, Facial Serums for Dry and Sensitive Skin Care with Hyaluronic Acid for Soft Smooth Skin, 2 Fl Oz

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

Proactiv Emergency Blemish Relief - Benzoyl Peroxide Gel - Acne Spot Treatment for Face and Body, .33 Oz

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment for Acne and Blackheads, Lightweight Sheerness, Safe For Sensitive Skin ,0.7 Fl Oz

Neutrogena Stubborn Acne Spot Drying Lotion, Fragrance-Free Sulfur Acne Treatment Clears Acne By Drying Up & Shrinking Pimples, Paraben- & Oil-Free, 10% Sulfur & 4% Niacinamide, 1.0 fl. oz

Dark Spot Treatments

Pimple Spot Treatments

Age Spot Treatments

Acne Spot Treatments