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Nighttime Decongestants

10 Best Nighttime Decongestants 2025 in the United States

Name: ZzzQuil ULTRA, Sleep Aid, Nighttime Sleep Aid, 25 mg Doxylamine Succinate, From Makers of Nyquil, Non- Habit Forming, Fall Asleep Fast, Stay Asleep Longer, 48 Count
Brand: ZzzQuil
Price: 19.63 USD
Availability: InStock

From leading brands and best sellers available on the web.

Winner

ZzzQuil

ZzzQuil ULTRA, Sleep Aid, Nighttime Sleep Aid, 25 mg Doxylamine Succinate, From Makers of Nyquil, Non- Habit Forming, Fall Asleep Fast, Stay Asleep Longer, 48 Count

9.9

score

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Hyland's

Editor’s Choice

Hyland's Kids Cold & Cough, Nighttime Cough Syrup Medicine for Kids Ages 2+, Decongestant, Sore Throat, Allergy & Sleeplessness Relief of Common Cold Symptoms, 4 Fl Oz

9.8

score

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Hyland's

Editor’s Choice

Hyland's Baby Mucus and Cold Relief, Day & Night Value Pack, Infant And Baby Cold Medicine, Decongestant And Cough Relief, 8 Fl Oz

9.8

score

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Amazon Basic Care

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)

9.7

score

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GenCare

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

9.6

score

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Hyland's

Hyland’s Baby Tiny Cold Tablets, Day & Night Value Pack, Infant and Baby Cold Medicine, Decongestant, Runny Nose & Cough Relief, 250 Quick-Dissolving Tablets

9.4

score

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Mucinex

Mucinex Fast-Max & NightShift Combo Pack - Max Strength Cough & Cold Medicines For Mucus Relief, Chest Congestion, Nasal Congestion, Sinus Congestion, Sinus Pressure, Cough Symptom Relief (2x 6 FL OZ)

9.2

score

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Hyland's

Editor’s Choice

Hyland's Kids Cold & Cough, Nighttime Grape Flavor Cough Syrup Medicine for Kids Ages 2+, Decongestant, Sore Throat, Allergy & Sleeplessness Relief of Common Cold Symptoms, 4 Fl Oz

9.0

score

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Vicks

Vicks NyQuil Cold and Flu Relief Liquid Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Sneezing, Runny Nose, and Cough, 48 Liquicaps

8.8

score

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#10

Mucinex

Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz

8.6

score

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10 Best Nighttime Decongestants 2025 in the United States

ZzzQuil ULTRA, Sleep Aid, Nighttime Sleep Aid, 25 mg Doxylamine Succinate, From Makers of Nyquil, Non- Habit Forming, Fall Asleep Fast, Stay Asleep Longer, 48 Count

Hyland's Kids Cold & Cough, Nighttime Cough Syrup Medicine for Kids Ages 2+, Decongestant, Sore Throat, Allergy & Sleeplessness Relief of Common Cold Symptoms, 4 Fl Oz

Hyland's Baby Mucus and Cold Relief, Day & Night Value Pack, Infant And Baby Cold Medicine, Decongestant And Cough Relief, 8 Fl Oz

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

Coricidin HBP, Decongestant-Free Cold Symptom Relief for People with High Blood Pressure, Maximum Strength Cold & Flu Day + Night Liquid Gels, 24 Count

Amazon Basic Care Nighttime Cold & Flu, 24 Softgels

Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

Robitussin Honey Nighttime Cough DM Max - Controls Cough, Runny Nose and Sneezing - Adult Formula, 4 Fl Oz

ARM & HAMMER Simply Saline Nighttime Nasal Mist 4.6oz- Instant Relief for SEVERE Congestion- One 4.6oz Bottle

Hyland’s Baby Tiny Cold Tablets, Day & Night Value Pack, Infant and Baby Cold Medicine, Decongestant, Runny Nose & Cough Relief, 250 Quick-Dissolving Tablets

Mucinex Fast-Max & NightShift Combo Pack - Max Strength Cough & Cold Medicines For Mucus Relief, Chest Congestion, Nasal Congestion, Sinus Congestion, Sinus Pressure, Cough Symptom Relief (2x 6 FL OZ)

Hyland's Kids Cold & Cough, Nighttime Grape Flavor Cough Syrup Medicine for Kids Ages 2+, Decongestant, Sore Throat, Allergy & Sleeplessness Relief of Common Cold Symptoms, 4 Fl Oz

Vicks NyQuil Cold and Flu Relief Liquid Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Sneezing, Runny Nose, and Cough, 48 Liquicaps

Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz

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