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Cold Sore Medicines

10 Best Cold Sore Medicines 2025 in the United States

Name: Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count
Brand: Mederma
Price: 9.79 USD
Availability: InStock

From leading brands and best sellers available on the web.

Kids Cold Medicine for Ages 2+, Hyland's Naturals Kids Cold & Cough, Day and Night Value Pack, Grape Syrup, Cough Medicine for Kids, 4 Fl Oz Each, 2 Count (Pack of 1)

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Winner

Mederma

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

9.9

score

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Kids Cold Medicine for Ages 2+, Hyland's Naturals Kids Cold & Cough, Day and Night Value Pack, Grape Syrup, Cough Medicine for Kids, 4 Fl Oz Each, 2 Count (Pack of 1)

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Mucinex

Mucinex Fast-Max Cold and Flu & Nightshift Severe Cold and Flu Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicines, 2 x 6 Fl Oz

9.8

score

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Boiron

Boiron ColdCalm Tablets for Relief of Common Cold Symptoms Such as Sneezing, Runny Nose, Sore Throat, and Nasal Congestion - Non-Drowsy - 60 Count

9.8

score

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Abreva

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

9.7

score

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Abreva

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

9.6

score

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Zicam

Zicam Cold Remedy Zinc Medicated Fruit Drops, Elderberry, Homeopathic, Cold Shortening Medicine, Shortens Cold Duration, 25 Count

9.4

score

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Quantum

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

9.3

score

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Clear Probiotics

Editor’s Choice

Cold Sore Treatment for Lips - Lysine Supercharged with Acidophilus Probiotic & Lactobacillus Rhamnosus + Vitamin C for Lip and Skin Health - Immune Support for Effective Prevention and Clear Skin

9.1

score

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TARO

TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 1 Tube)

8.9

score

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#10

ALKA-SELTZER PLUS

Alka-seltzer Plus New Cough & Sore Throat Fizzy Chews, No Water Needed, On The Go Sore Throat Relief, Cough Relief for Adults, Cough and Sore Throat Chewable Tablets, Raspberry Flavor, 24 Count

8.6

score

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More products we considered

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

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Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu (500 Count (Pack of 1))

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HealthA2Z® Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (20 Softgels) (20 Softgels)

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HealthA2Z® Daytime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime(20 Softgels) (Daytime Cold & Flu Medicine (20 Count Pack of 1))

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HealthA2Z® Mucus Relief | Guaifenesin 400mg | Immediate Release | No Benzene | Expectorant (150 Counts)

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How do we rank products for you?

Our technology thoroughly searches through the online shopping world, reviewing hundreds of sites. We then process and analyze this information, updating in real-time to bring you the latest top-rated products. This way, you always get the best and most current options available.

10 Best Cold Sore Medicines 2025 in the United States

Kids Cold Medicine for Ages 2+, Hyland's Naturals Kids Cold & Cough, Day and Night Value Pack, Grape Syrup, Cough Medicine for Kids, 4 Fl Oz Each, 2 Count (Pack of 1)

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

Kids Cold Medicine for Ages 2+, Hyland's Naturals Kids Cold & Cough, Day and Night Value Pack, Grape Syrup, Cough Medicine for Kids, 4 Fl Oz Each, 2 Count (Pack of 1)

Mucinex Fast-Max Cold and Flu & Nightshift Severe Cold and Flu Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicines, 2 x 6 Fl Oz

Boiron ColdCalm Tablets for Relief of Common Cold Symptoms Such as Sneezing, Runny Nose, Sore Throat, and Nasal Congestion - Non-Drowsy - 60 Count

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

Hyland's - Kids - Organic Cough & Immune Day & Night Combo Pack - Eases Coughs, Supports Immunity, Promotes Sleep, Two 4 Fl Oz. Bottles (8 fl oz) (Pack of 2)

Herbion Naturals Respiratory Care Herbal Granules – 10 Ct for The Whole Family – Promotes Healthy Nasal Passages & Respiratory Function - Relieves Cold and Flu Symptoms – Supports Immune System

HealthA2Z® Mucus Relief | Guaifenesin 600 mg | 12 Hour | No Benzene | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus | Extended Release (150 Counts)

HealthA2Z® Mucus Relief DM | Dextromethorphan HBr 20mg | Guaifenesin 400mg | No Benzene | Cough, Immediate Release, Uncoated (120 Count (Pack of 1))

HealthA2Z® Mucus Relief | Guaifenesin 1200 mg | NO Benzene |100 Tablets | Maximum Strength | 12 Hour | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus

Zicam Cold Remedy Zinc Medicated Fruit Drops, Elderberry, Homeopathic, Cold Shortening Medicine, Shortens Cold Duration, 25 Count

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

Cold Sore Treatment for Lips - Lysine Supercharged with Acidophilus Probiotic & Lactobacillus Rhamnosus + Vitamin C for Lip and Skin Health - Immune Support for Effective Prevention and Clear Skin

TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 1 Tube)

Alka-seltzer Plus New Cough & Sore Throat Fizzy Chews, No Water Needed, On The Go Sore Throat Relief, Cough Relief for Adults, Cough and Sore Throat Chewable Tablets, Raspberry Flavor, 24 Count

Medicines Colds

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Medicine For Cold Sores

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Cold Flu Medicines

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu (500 Count (Pack of 1))

HealthA2Z® Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (20 Softgels) (20 Softgels)

HealthA2Z® Daytime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime(20 Softgels) (Daytime Cold & Flu Medicine (20 Count Pack of 1))

HealthA2Z® Mucus Relief | Guaifenesin 400mg | Immediate Release | No Benzene | Expectorant (150 Counts)